4,5',8-Trimethylpsoralen

CAS: 3902-71-4

Ref. 3D-FT47227

Product Information

• Name: 4,5',8-Trimethylpsoralen
• Synonyms: Trioxsalen2,5,9-Trimethyl-furo[3,2-g]benzopyran-7-one, 5-Benzofuranacrylic acid, 6-hydroxy-β,2,7-trimethyl-, δ-lactone, 4,5′,8-Trimethylpsoralen, 2,5,9-Trimethyl-7H-furo[3,2-g][1]benzopyran-7-one, Trioxsalen, 7H-Furo[3,2-g][1]benzopyran-7-one, 2,5,9-trimethyl-

Description

4,5',8-Trimethylpsoralen is a fatty acid that can be synthesized from para-aminobenzoic acid. It has been shown to have carcinogenic potential in vitro and in vivo. 4,5',8-Trimethylpsoralen inhibits transcription by binding to DNA polymerase II and III. This inhibition prevents the production of RNA and protein synthesis, leading to cell death. 4,5',8-Trimethylpsoralen also inhibits DNA synthesis by binding to the enzyme DNA gyrase and topoisomerase IV. It is not active against some bacteria that are resistant to other drugs due to the presence of mutations in their genes encoding for the target enzymes. 4,5',8-Trimethylpsoralen has been shown to inhibit autoimmune diseases such as arthritis and lupus erythematosus.br>br>4,5',8-Trimethylpsoralen is most commonly used as

• Brand: Biosynth

Chemical properties

• Molecular weight: 228.24 g/mol
• Formula: C₁₄H₁₂O₃
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C14H12O3/c1-7-4-12(15)17-14-9(3)13-10(6-11(7)14)5-8(2)16-13/h4-6H,1-3H3
• InChI key: InChIKey=FMHHVULEAZTJMA-UHFFFAOYSA-N
• SMILES: Cc1cc2cc3c(C)cc(=O)oc3c(C)c2o1