3,4,5-trimethoxybenzyl cyanide

CAS: 13338-63-1

Ref. 3D-FT54817

Product Information

• Name: 3,4,5-trimethoxybenzyl cyanide
• Synonyms: 3,4,5-trimethoxyphenylacetonitrile, (3,4,5-Trimethoxyphenyl)acetonitrile, 2-(3,4,5-Trimethoxyphenyl)acetonitrile, 3,4,5-Trimethoxybenzeneacetonitrile, 3,4,5-Trimethoxybenzyl cyanide, 3,4,5-Trimethoxybenzylnitrile, 3,4,5-Trimethoxyphenylacetionitrile, Acetonitrile, (3,4,5-trimethoxyphenyl)-, Benzeneacetonitrile, 3,4,5-trimethoxy-, NSC 97556

Description

3,4,5-Trimethoxybenzyl cyanide is a natural product that has been shown to inhibit the polymerase of bacterial RNA and DNA. It binds to the active site of the enzyme and prevents its function. The mechanism of 3,4,5-trimethoxybenzyl cyanide is similar to that of other inhibitors of bacterial RNA polymerase such as quinacrine and actinomycin D. This compound has also been shown to prevent fibrillation in vitro. 3,4,5-Trimethoxybenzyl cyanide has antiarrhythmic properties. It blocks the mitochondrial membrane potential by inhibiting the synthesis of ATP. This inhibition leads to an increased permeability of the mitochondrial membrane for ions such as potassium and calcium. The increased permeability leads to a decrease in cellular excitability and a decrease in cardiac arrhythmias (irregular heartbeats).

• Brand: Biosynth

Chemical properties

• Molecular weight: 207.23 g/mol
• Formula: C₁₁H₁₃NO₃
• Purity: Min. 97 Area-%
• Color/Form: Powder