Tri(m-tolyl)phosphine

Ref. 3D-FT61053

Product Information

• Name: Tri(m-tolyl)phosphine
• Synonyms: Tris(3-methylphenyl)phosphine
• Brand: Biosynth
• Description: Tri(m-tolyl)phosphine is an organophosphorus compound that inhibits the polymerization of polyvinyl chloride. It has been shown to inhibit the growth of fibroblast cells in vitro and has a cytotoxic effect on human adenocarcinoma cells. Tri(m-tolyl)phosphine binds to the active site of polymerase, thereby inhibiting DNA synthesis by preventing incorporation of nucleotide monomers into the growing chain. The binding constants for tri(m-tolyl)phosphine to calf-thymus DNA and human adenocarcinoma cell DNA are 1.7 x 10 M and 1.4 x 10 M, respectively. This molecule is also a potent inhibitor of heterocyclic amines, which have been implicated as cancer-causing agents in cooked meat products such as bacon and hot dogs.

Chemical properties

• Molecular weight: 304.37 g/mol
• Formula: C₂₁H₂₁P
• Purity: Min. 95%
• InChI: InChI=1S/C21H21P/c1-16-7-4-10-19(13-16)22(20-11-5-8-17(2)14-20)21-12-6-9-18(3)15-21/h4-15H,1-3H3
• InChI key: InChIKey=LFNXCUNDYSYVJY-UHFFFAOYSA-N
• SMILES: Cc1cccc(P(c2cccc(C)c2)c2cccc(C)c2)c1