Tryptanthrin

CAS: 13220-57-0

Ref. 3D-FT66458

Product Information

• Name: Tryptanthrin
• Synonyms: Indolo[2,1-b]quinazoline-6,12-dione, Couroupitine A, Indolo(2,1-b)quinazoline-6,12-dione (8CI)(9CI), Indolo[2,1-B]Quinazoline-6,12-Dione, Nsc 349447, Triptantrin, Tryptanthrine

Description

Tryptanthrin is a natural compound that has been shown to inhibit the activity of P-glycoprotein (P-gp) by binding to its basic protein. Tryptanthrin has also been shown to be cytotoxic in bowel disease. Tryptanthrin has a significant cytotoxicity against HL60 cells, which is due to its ability to inhibit the activity of cyclin D2. This agent also inhibits the proliferation of HL60 cells induced by oxidative injury, and can be used as an anti-cancer therapeutic. Molecular docking analysis suggests that tryptanthrin binds with high affinity to the ATPase region of P-gp.

• Brand: Biosynth

Chemical properties

• Molecular weight: 248.24 g/mol
• Formula: C₁₅H₈N₂O₂
• Purity: Min. 95%
• Color/Form: White Powder
• InChI: InChI=1S/C15H8N2O2/c18-13-10-6-2-4-8-12(10)17-14(13)16-11-7-3-1-5-9(11)15(17)19/h1-8H
• InChI key: InChIKey=VQQVWGVXDIPORV-UHFFFAOYSA-N
• SMILES: O=C1c2ccccc2-n2c1nc1ccccc1c2=O