Tris(4-fluorophenyl)phosphine oxide

CAS: 18437-79-1

Ref. 3D-FT99101

Product Information

• Name: Tris(4-fluorophenyl)phosphine oxide
• Synonyms: Trisfluorophenylphosphine, Trispfluorophenylphosphine, Tris(4-Fluorophenyl)Phosphane Oxide

Description

Tris(4-fluorophenyl)phosphine oxide (TFPO) is a phosphine-based organocatalyst that is used to catalyze a variety of reactions, including β-unsaturated ketones. TFPO has been shown to be effective at activating peroxide and stabilizing lanthanum. The phosphine moiety can bind in a stereospecific fashion with the metal center, which facilitates the formation of the reactive intermediate. This mechanism of activation has been studied systematically and is known for its ability to provide an efficient synthetic route to β-unsaturated ketones. TFPO also activates molecules, such as alkenes, by focusing on the transition state and stabilizing it through catalysis. These reactions have been applied in organic synthesis to produce new molecules with pharmaceutical potentials.

• Brand: Biosynth

Chemical properties

• Molecular weight: 332.26 g/mol
• Formula: C₁₈H₁₂F₃OP
• Purity: Min. 95%
• InChI: InChI=1S/C18H12F3OP/c19-13-1-7-16(8-2-13)23(22,17-9-3-14(20)4-10-17)18-11-5-15(21)6-12-18/h1-12H
• InChI key: InChIKey=VSJZSGXKNZYQPR-UHFFFAOYSA-N
• SMILES: O=P(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1