D-Valinol

CAS: 4276-09-9

Ref. 3D-FV36829

Product Information

• Name: D-Valinol
• Synonyms: (R)-2-Amino-3-methyl-1-butanolD-D-Val-ol, (-)-2-Amino-3-methyl-1-butanol, (-)-Valinol, (2R)-2-Amino-3-methyl-1-butanol, (2R)-2-Amino-3-methylbutan-1-ol, (R)-(-)-2-Amino-3-methyl-1-butanol, (R)-2-Amino-3-methylbutan-2-ol, (R)-2-Amino-3-methylbutanol, (R)-2-amino-3-methylbutan-1-ol, (R)-Valinol, 1-Butanol, 2-amino-3-methyl-, (2R)-, 1-Butanol, 2-amino-3-methyl-, (R)-, 1-Butanol, 2-amino-3-methyl-, <span class="text-smallcaps">D</span>-, <span class="text-smallcaps">D</span>-Valinol, D-valinol (R-2-amino-3-methyl-1-butanol), [(R)-1-(Hydroxymethyl)-2-methylpropyl]amine

Description

D-Valinol is a synthetic compound that contains a chiral alcohol group. It is an ester hydrochloride salt of D-valinol and has been shown to be clinically effective in treating chronic lymphocytic leukemia (CLL). This drug is a potent inhibitor of the bcr-abl kinase, which is involved in the regulation of protein synthesis. D-Valinol binds to the kinase domain of this enzyme and inhibits its activity by preventing it from transferring phosphate groups from ATP to tyrosine residues on proteins. D-Valinol also inhibits chloride channels, which are required for cell survival.

• Brand: Biosynth

Chemical properties

• Molecular weight: 103.16 g/mol
• Formula: C₅H₁₃NO
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C5H13NO/c1-4(2)5(6)3-7/h4-5,7H,3,6H2,1-2H3/t5-/m0/s1
• InChI key: InChIKey=NWYYWIJOWOLJNR-YFKPBYRVSA-N
• SMILES: CC(C)[C@@H](N)CO