Withaferin A

CAS: 5119-48-2

Ref. 3D-FW32226

Product Information

• Name: Withaferin A
• Synonyms: (4b,5b,6b,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2 ,24-dien-26-oic acid d-lactone5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2 ,24-dienolide, (4b,5b,6b,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic Acid d-Lactone, 4b,27-Dihydroxy-1-oxo-5b,6b-epoxywitha-2,24-dienolide, 5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic Acid d-Lactone, 5,6-Epoxy-5H-cyclopenta[a]phenanthrene, ergosta-2,24-dien-26-oic acid deriv., 5β-Ergosta-2,24-dien-26-oic acid, 5,6β-epoxy-4β,22,27-trihydroxy-1-oxo-, δ-lactone, (20S,22R)-, Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-4,22,27-trihydroxy-1-oxo-, δ-lactone, (4β,5β,6β,22R)-, NSC 101088, NSC 273757, Withaferine, Withaferine A

Description

Withaferin A is a natural compound that belongs to the group of diterpenoids. It is a potent inhibitor of DNA polymerase, with minimal toxicity and no cytotoxicity at concentrations up to 5 μM. Withaferin A has been shown to have antibacterial efficacy against Gram-positive bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus faecalis, and Bacillus subtilis. Withaferin A binds to the promoter region of the bcl-2 gene, inhibiting transcription and translation. The binding of withaferin A causes an increase in tumor necrosis factor alpha (TNFα) levels and reduces the expression of interleukin-6 (IL-6). This molecule also has inhibitory properties on neural cells by binding to response elements.

• Brand: Biosynth

Chemical properties

• Molecular weight: 470.6 g/mol
• Formula: C₂₈H₃₈O₆
• Purity: Min. 98 Area-%
• Color/Form: White Powder