Yohimbe bark

CAS: 146-48-5

Ref. 3D-FY01219

Product Information

• Name: Yohimbe bark
• Synonyms: Yohimbine, 17Alpha-Hydroxy-Yohimban-16Alpha-Carboxylic Acid Methyl Ester, Aphrodine, Aphrosol, Benz[g]indolo[2,3-a]quinolizine, yohimban-16-carboxylic acid deriv., Corynine, Methyl (16Alpha,17Alpha)-17-Hydroxyyohimban-16-Carboxylate, Methyl (16Alpha,17Alpha)-17-Hydroxyyohimban-16-Carboxylate Hydrochloride (1:1), Quebrachin, Quebrachine, Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16α,17α)-, Yohimban-16α-carboxylic acid, 17α-hydroxy-, methyl ester, Yohimbic acid methyl ester, Yohimbin, Yohimbina, Yohimbol-16α-carboxylic acid, methyl ester, trans-Quinolizidine yohimbine

Description

Yohimbe bark is a natural product that has been used for centuries to treat an array of conditions including infectious diseases, sexual dysfunction, and depression. The active ingredient of yohimbe bark is yohimbine, which belongs to the class of indole alkaloids. Yohimbine has been shown to have locomotor activity in rats. It also binds to pro-apoptotic proteins and neurotrophic factors, leading to the activation of biochemical reactions such as hydrogen tartrate decomposition and p450 activity.

Yohimbine can be found in the reaction solution after adding sodium citrate and human serum. Yohimbine hydrochloride is a potent inhibitor of esterases with a half-life in vivo of approximately 2 hours. Yohimbine hydrochloride also inhibits the growth of bacteria by binding to bacterial DNA gyrase and topoisomerase IV enzymes, preventing them from maintaining the integrity of bacterial DNA.

• Brand: Biosynth

Chemical properties

• Molecular weight: 354.44 g/mol
• Formula: C₂₁H₂₆N₂O₃
• Purity: Min. 98 Area-%
• Color/Form: Powder
• InChI: InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1
• InChI key: InChIKey=BLGXFZZNTVWLAY-SCYLSFHTSA-N
• SMILES: COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21