GDP-D-mannose disodium salt

CAS: 148296-46-2

Ref. 3D-G-8650

Product Information

• Name: GDP-D-mannose disodium salt
• Synonyms: Guanosine 5'-diphospho-alpha-D-mannose disodium salt GDP-Man
• Brand: Biosynth
• Description: GDP-D-mannose is a natural mannosyl donor and substrate for mannosyltransferases that catalyses mannosylation, for instance during the synthesis of the trimannoside core of complex, high-mannose or hybrid N-glycans. GDP-D-mannose is widely used in (chemo)enzymatic synthesis of oligosaccharides and its biosynthesis occurs from glucose-6-phosphate over several steps. GDP-D-mannose consists of a D-mannose unit, α-glycosydically linked to the nucleotide guanosine diphosphate (GDP). Examples of this important reaction would be the transfer of mannosyl moieties onto the dolichol-P-P-GlcNAc2 precursor of N-glycans in the endoplasmatic reticulum, with release of GDP, or the mannosylation reactions during GPI-anchor (bio)synthesis. GDP-D-mannose has also been used for the in vitro synthesis of b-mannan oligosaccharides.

Chemical properties

• Molecular weight: 649.3 g/mol
• Formula: C₁₆H₂₃N₅O₁₆P₂Na₂
• Purity: Min. 95 Area-%