Formycin A

CAS: 6742-12-7

Ref. 3D-GAA74212

Product Information

• Name: Formycin A
• Synonyms: (1S)-1-(7-amino-2H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol, (1S)-1-C-(7-Amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-<span class="text-smallcaps">D</span>-ribitol, (5R)-5-(7-amino-2H-pyrazolo[4,3-d]pyrimidin-3-yl)-2,5-anhydro-D-ribitol, 1-(7-amino-2H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydropentitol, 1H-Pyrazolo(4,3-d)pyrimidine, 7-amino-3-beta-D-ribofuranosyl-, 1H-Pyrazolo[4,3-d]pyrimidine, 7-amino-3-β-<span class="text-smallcaps">D</span>-ribofuranosyl-, 1H-Pyrazolo[4,3-d]pyrimidine, <span class="text-smallcaps">D</span>-ribitol deriv., 7-Amino-3-beta-D-ribofuranosyl-1H-pyrazolo(4,3-d)pyrimidine, 8-Aza-9-deazaadenosine, <span class="text-smallcaps">D</span>-Ribitol, 1-C-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-, (1S)-, Brn 0624229, D-Ribitol, 1-C-(7-amino-1H-pyrazolo(4,3-d)pyrimidin-3-yl)- 1,4-anhydro-, (S)- (9CI), Formycin, Nsc 102811, (1S)-1-C-(7-Amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol, 1H-Pyrazolo[4,3-d]pyrimidine, D-ribitol deriv., Formycin A, 1H-Pyrazolo[4,3-d]pyrimidine, 7-amino-3-β-D-ribofuranosyl-, D-Ribitol, 1-C-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-, (1S)-

Description

Formycin A is an equilibrative nucleoside with inhibitory properties. It has been shown to be active against infectious diseases such as leishmania, trypanosomes and chlamydia. Formycin A binds to the pyrazole ring of a protein called DCTPase, which is involved in the metabolism of purines and pyrimidines. This binding blocks the enzyme's activity and leads to the accumulation of cytosolic Ca2+, which triggers apoptosis. The effect of formycin A on this protein is reversible, so it can be used as a vaccine adjuvant or in combination with other antibiotics. Formycin A also has biochemical properties that allow it to act as an inhibitor for other proteins that are involved in DNA synthesis and rRNA transcription.

• Brand: Biosynth

Chemical properties

• Molecular weight: 267.24 g/mol
• Formula: C₁₀H₁₃N₅O₄
• Purity: Min. 95%