Product Information
Nanatinostat is a histone deacetylase inhibitor that selectively inhibits HDAC1 and HDAC2. It has been shown to be effective in the treatment of bladder cancer cells and chronic viral infections, but not in clinical development for other cancers. Nanatinostat inhibits the aminopeptidase activity of HDACs and prevents the removal of lysine residues from histones. This causes an increase in acetylation of nucleosomal histones, which results in transcriptional activation of genes that are associated with tumor suppression and apoptosis. Nanatinostat also modifies the fatty acid composition of cellular membranes by inhibiting fatty acid synthase, thereby causing lipid peroxidation-induced apoptosis.
Chemical properties
Technical inquiry about: 3D-GAC44847 Nanatinostat
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