(2E)-2-(Pyridin-3-ylmethylidene)-2,3-dihydro-1H-indene-1,3-dione

CAS: 31083-55-3

Ref. 3D-GBA08355

Product Information

• Name: (2E)-2-(Pyridin-3-ylmethylidene)-2,3-dihydro-1H-indene-1,3-dione
• Synonyms: 1,3-Indandione, 2-(3-pyridylmethylene)-, 1H-indene-1,3(2H)-dione, 2-(3-pyridinylmethylene)-, 2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione, 2-(3-Pyridylmethylene)-1,3-indandione, 2-(Pyridin-3-ylmethylene)-1H-indene-1,3(2H)-dione, 2-(Pyridin-3-ylmethylidene)indene-1,3-dione, 2-Pyridin-3-ylmethylene-indan-1,3-dione, 2-[(Pyridin-3-yl)methylidene]-2,3-dihydro-1H-indene-1,3-dione, NSC 600157, Prt 4165, Sml 1013

Description

(2E)-2-(Pyridin-3-ylmethylidene)-2,3-dihydro-1H-indene-1,3-dione is a fluorescent probe that emits light in response to contact with the enzyme caspase 3. It has been shown to be effective in monitoring the activity of caspase 3 in cells and tissues. This probe is used for the treatment of cancer by apoptosis induction and DNA fragmentation. It acts as an anti-cancer agent by binding to the protein transfer which inhibits the proteasome from degrading proteins that are involved in cell proliferation. This leads to accumulation of these proteins, which cause cells to die through apoptosis.

• Brand: Biosynth

Chemical properties

• Molecular weight: 235.24 g/mol
• Formula: C₁₅H₉NO₂
• Purity: Min. 95%