Product Information
Neuron-specific enolase human is a protein that in humans is encoded by the NES gene. Neuron-specific enolase (NSE) is a neuron-specific, glycolytic enzyme with a molecular weight of 34,000 Daltons. It is released into the blood and cerebrospinal fluid as a result of neuronal damage. NSE is also found in the skeletal muscle and heart tissue, but at levels much lower than those found in the brain. In wild-type mice, NSE expression was shown to be regulated by endogenous adenosine, which acts as an autocrine regulator of neuronal function. The adenosine receptor antagonist caffeine increased NSE expression in wild-type mice and reduced it in transgenic animals that lack endogenous adenosine signalling. Caffeine also had an inhibitory effect on uptake of labelled purines into cerebral cortex cells and induced excitatory effects on adenosine receptors.
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