Product Information
ANI-7 is a hydrophobic naphthalimide derivative that has been shown to be cytotoxic to cancer cells. It activates the death mediated pathway by binding with the cell surface receptor and then inhibiting the molecule which regulates this process, piperazine. ANI-7 also inhibits DNA synthesis by binding to the acrylonitrile hydroxylase and preventing its activation. This leads to a decrease in cellular DNA content and subsequently cell death. The molecule is also metabolised by cytochrome P450 enzymes, which may explain why it has been found in some cases to be more cytotoxic than other derivatives of naphthalimides.
Chemical properties
Technical inquiry about: 3D-GMB41726 ANI-7
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