PS-1145

CAS: 431898-65-6

Ref. 3D-GSA89865

Product Information

• Name: PS-1145
• Synonyms: N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide
• Brand: Biosynth
• Description: PS-1145 is a chemical inhibitor that belongs to the class of small molecule inhibitors. PS-1145 binds to the IL2 receptor and blocks the activation of BCL-2 protein, leading to cell death by inhibiting the production of proteins vital for cell division. It also inhibits inhibitory proteins such as IκBα and NEMO, which are important for NF-κB signaling. PS-1145 induces oxidative injury and caspase-independent cell death in cells by binding to DNA at response elements, thereby inhibiting transcriptional activity.

Chemical properties

• Molecular weight: 322.75 g/mol
• Formula: C₁₇H₁₁ClN₄O
• Purity: Min. 95%