Product Information
NSC 81178 is a sulfur-containing chemical that was found to be capable of inducing mutations in the DNA of Neurospora crassa. The mutant strain of N. crassa, which responded positively to NSC 81178, had a reduced capacity for conversion of 5-formyluracil to 5-hydroxymethyluracil and showed a decreased level of glutarate synthesis. This suggests that NSC 81178 may be capable of inducing mutations by chemically reacting with DNA and altering its structure.
In addition, the KM values for pyrimidines were significantly higher in the mutant strain than in the wild type strain, indicating that NSC 81178 has an effect on nucleotide synthesis.
Chemical properties
Technical inquiry about: 3D-HAA57792 NSC 81178
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