Aceclofenac ethyl ester

CAS: 139272-67-6

Ref. 3D-IA16910

Product Information

• Name: Aceclofenac ethyl ester
• Synonyms: 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid 2-ethoxy-2-oxoethyl ester
• Brand: Biosynth
• Description: Aceclofenac ethyl ester is a prodrug of diclofenac. It is a non-steroidal anti-inflammatory drug that alleviates the symptoms of pain, stiffness, and swelling. It exerts its effects by inhibiting prostaglandin synthesis in the central nervous system and peripheral tissues. Aceclofenac ethyl ester has minimal systemic absorption when administered orally, which reduces the risk of side effects such as stomach upset and kidney damage. The pharmacopoeia provides an efficient method for preparing this compound by reacting diclofenac with magnesium stearate in a solvent containing an organic amine or alcohol at temperatures below 50°C (122°F). Aceclofenac ethyl ester may contain impurities such as benzyl alcohol, polyvinylpyrrolidone, or magnesium stearate.

Chemical properties

• Molecular weight: 382.24 g/mol
• Formula: C₁₈H₁₇Cl₂NO₄
• Purity: Min. 95 Area-%
• Color/Form: Powder
• InChI: InChI=1S/C18H17Cl2NO4/c1-2-24-17(23)11-25-16(22)10-12-6-3-4-9-15(12)21-18-13(19)7-5-8-14(18)20/h3-9,21H,2,10-11H2,1H3
• InChI key: InChIKey=JDOYJDOPEHMRPB-UHFFFAOYSA-N
• SMILES: CCOC(=O)COC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl