Aceclofenac methyl ester

CAS: 139272-66-5

Ref. 3D-IA16911

Product Information

• Name: Aceclofenac methyl ester
• Synonyms: 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid 2-methoxy-2-oxoethyl ester
• Brand: Biosynth
• Description: Aceclofenac methyl ester is an analgesic that belongs to the arylpropionic acid derivatives. It has been developed for the treatment of acute pain. Aceclofenac methyl ester has a structural formula of CH3CO-O-CH3 and a molecular weight of 164.2 g/mol. Aceclofenac is metabolized by CYP450 enzymes, which are located in the liver and other organs, to form acetic acid and 5-hydroxyaceclofenac. The reaction time is approximately 1 hour and tetrahydrofuranyl (THF) is used as a nucleophile in this reaction. This product can be synthesized by reacting ethyl acetate with acetonitrile in high yield, making it stable and anhydrous. The analgesic effects of aceclofenac methyl ester are due to its ability to block the transmission of pain signals from nerves to the brain at the spinal cord level

Chemical properties

• Molecular weight: 368.21 g/mol
• Formula: C₁₇H₁₅Cl₂NO₄
• Purity: Min. 98 Area-%
• Color/Form: White Powder
• InChI: InChI=1S/C17H15Cl2NO4/c1-23-16(22)10-24-15(21)9-11-5-2-3-8-14(11)20-17-12(18)6-4-7-13(17)19/h2-8,20H,9-10H2,1H3
• InChI key: InChIKey=CYRWXOBAPNKPIF-UHFFFAOYSA-N
• SMILES: COC(=O)COC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl