Atorvastatin lactone

CAS: 125995-03-1

Ref. 3D-IA18019

Product Information

• Name: Atorvastatin lactone
• Synonyms: 5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N,4-diphenyl-2-propan-2-ylpyrrole-3-carboxamide
• Brand: Biosynth
• Description: Atorvastatin lactone is a prodrug for atorvastatin. It is an inhibitor of the enzyme HMG-CoA reductase, which is involved in cholesterol synthesis and reduces LDL cholesterol levels. Atorvastatin lactone is absorbed from the gut into the bloodstream and then converted to atorvastatin, which has a higher potency than atorvastatin lactone. This conversion occurs in the liver by cytochrome P450 enzymes, including cytochrome CYP3A4. The pharmacokinetics of atorvastatin lactone are influenced by drugs that inhibit these enzymes. Atorvastatin and its metabolites are excreted in human serum as glucuronide or sulfate conjugates.

Chemical properties

• Molecular weight: 540.62 g/mol
• Formula: C₃₃H₃₃FN₂O₄
• Purity: Min. 98 Area-%
• Color/Form: Powder