Product Information
TH 1338 is an anhydride that has been synthesized as a precursor to anticancer drugs. It is a camptothecin derivative and inhibits the proliferation of cancer cells. TH 1338 was found to inhibit the proliferation of human erythrocytes in vitro and also inhibited the growth of sarcoma 180 in vivo. Hyperproliferative diseases such as leukemia, lymphoma, and carcinomas are associated with abnormal cell division. The inhibiting effects of TH 1338 on cell replication may be due to its ability to bind to DNA gyrase, topoisomerase II, or topoisomerase IV enzymes, which are required for DNA replication. This binding prevents the formation of an enzyme-substrate complex required for DNA synthesis and cell division.
Chemical properties
Technical inquiry about: 3D-IAC49460 TH 1338
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