Chlorhexidine digluconate EP Impurity L

Ref. 3D-IC176165

Product Information

• Name: Chlorhexidine digluconate EP Impurity L
• Synonyms: (5R,6S)-2-[(4-Chlorophenyl)amino]-5-hydroxy-6-[(1R,2R)1,2,3-trihydroxypropyl]-5,6-dihydro-4H-1,3-oxazin-4-one
• Brand: Biosynth
• Description: Chlorhexidine digluconate EP Impurity L is a metabolite of chlorhexidine digluconate. It is an impurity found in the drug product, which is used for the treatment of skin and mucous membrane infections. The mechanism of action for chlorhexidine digluconate EP Impurity L is not known. However, it has been shown to be metabolized by CYP3A4 and CYP2C9 enzymes to form chlorhexidine acetate, a metabolite that inhibits bacterial growth, and hydrolyzed by esterases to form 2-hydroxychlorhexidine acetate. This metabolite has been found in the urine of rats following oral administration with chlorhexidine digluconate EP Impurity L.

Chemical properties

• Molecular weight: 330.72 g/mol
• Formula: C₁₃H₁₅ClN₂O₆
• Purity: Min. 95%