6α-Chloro-17-acetoxy progesterone

CAS: 2477-73-8

Ref. 3D-IC19976

Product Information

• Name: 6α-Chloro-17-acetoxy progesterone
• Synonyms: (6?)-17-(Acetyloxy)-6-chloropregn-4-ene-3,20-dione6?-Chloro-17-hydroxypregn-4-ene-3,20-dione acetate6?-Chloro-17-hydroxyprogestero ne acetate, (6α)-17-(Acetyloxy)-6-chloropregn-4-ene-3,20-dione, 17-Acetoxy-6α-chloropregn-4-ene-3,20-dione, 6.alpha.-Chloro-17-acetoxyprogesterone, 6.alpha.-Chloro-17-hydroxyprogesterone acetate, 6alpha-Chloro-17-hydroxypregn-4-ene-3,20-dione acetate, 6α-Chloro-17-acetoxyprogesterone, 6α-Chloro-17-hydroxyprogesterone acetate, Hydromadinone acetate, NSC 33170, Pregn-4-Ene-3,20-Dione, 17-(Acetyloxy)-6-Chloro-, (6Alpha)-, Pregn-4-ene-3,20-dione, 17- (acetyloxy)-6-chloro-, (6.alpha.)-, Pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-chloro-, (6α)-, Pregn-4-ene-3,20-dione, 6alpha-chloro-17-hydroxy-, acetate (8CI), Pregn-4-ene-3,20-dione, 6α-chloro-17-hydroxy-, acetate, Progesterone, 6.alpha.-chloro-17-hydroxy-, acetate, Progesterone, 6α-chloro-17-hydroxy-, acetate

Description

6alpha-Chloro-17-acetoxy progesterone is a synthetic, nonsteroidal estrogen. It is a potent inhibitor of the proliferation of human breast cancer cells in vitro and in vivo. Progesterone has been shown to inhibit the growth rate of human breast cancer cells by blocking the cell cycle at G2/M phase, with no effect on DNA synthesis or mitosis. The parameters for monitoring the growth rates are average rates, transport rates, and overlapped rates. The average growth rate is calculated as the proportionality between the number of events and time intervals. Transport rates are expressed as the ratio between an event type and time intervals. Overlapped rates are expressed as the ratio between two types of events that occur during overlapping time intervals. 6alpha-Chloro-17-acetoxy progesterone has been envisaged to be used as a treatment for hormone receptor positive breast cancer patients who have failed initial endocrine therapy and are not candidates for chemotherapy due

• Brand: Biosynth

Chemical properties

• Molecular weight: 406.94 g/mol
• Formula: C₂₃H₃₁ClO₄
• Purity: Min. 95%