N-De[2-(methylsulfonyl)ethyl] lapatinib

CAS: 697299-82-4

Ref. 3D-ID20812

Product Information

• Name: N-De[2-(methylsulfonyl)ethyl] lapatinib
• Synonyms: 6-[5-(Aminomethyl)-2-furanyl]-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-4-quinazolinamine[6-(5-Aminomethylfuran-2-yl)quinazoli n-4-yl][3-chloro-4-(3-fluorobenzyloxy)phenyl]amineLapatinib impurity
• Brand: Biosynth
• Description: Lapatinib is a tyrosine kinase inhibitor that blocks the epidermal growth factor receptor (EGFR) and other tyrosine kinases. It is used in cancer treatment to inhibit tumor growth, with a high success rate. Lapatinib is also used to treat lung cancer and other types of cancer. The drug has been shown to inhibit EGFR phosphorylation in vitro, which leads to inhibition of cell proliferation and induction of apoptosis. Lapatinib also inhibits the expression of EGFR downstream target genes such as b-raf, serine/threonine-protein kinase, and cyp3a5.

Chemical properties

• Molecular weight: 474.91 g/mol
• Formula: C₂₆H₂₀ClFN₄O₂
• Purity: Min. 95%
• InChI: InChI=1S/C26H20ClFN4O2/c27-22-12-19(5-8-25(22)33-14-16-2-1-3-18(28)10-16)32-26-21-11-17(4-7-23(21)30-15-31-26)24-9-6-20(13-29)34-24/h1-12,15H,13-14,29H2,(H,30,31,32)
• InChI key: InChIKey=NQHFMDSFFGTFSK-UHFFFAOYSA-N
• SMILES: NCc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1