Product Information
- (1S,3S,5E,13E,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl (2E,4E)-octa-2,4-dienoate
- (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1~3,7~.1~11,15~]nonacos-8-en-12-yl (2E,4E)-octa-2,4-dienoate
- 18,27,28,29-Tetraoxatetracyclo[21.3.1.1<sup>3,7</sup>.1<sup>11,15</sup>]nonacosane, bryostatin 1 deriv.
- 2,4-Octadienoic acid, (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1<sup>3,7</sup>.1<sup>11,15</sup>]nonacos-8-en-12-yl ester, (2E,4E)-
- 2,4-Octadienoic acid, 25-(acetyloxy)-1,11,21-trihydroxy-17-(1-hydroxyethyl)-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1<sup>3,7</sup>.1<sup>11,15</sup>]nonacos-8-en-12-yl ester, [1S-[1R*,3R*,5Z,7S*,8E,11R*,12R*(2E,4E),13E,15R*,17S*(S*),21S*,23S*,25R*]]-
- Bmy-45618
- Nsc-339555
- [1S-[1R*,3R*,5Z,7S*,8E,11R*,12R*(2E,4E),13E,15R*,17S*(S*),21S*,23S*,25R*]]-25-(Acetyloxy)-1,11,21-trihydroxy-17-(1-hydroxyethyl)-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1<sup>3,7</sup>.1<sup>11,15</sup>]nonacos-8-en-12-yl 2,4-octadienoate
Bryostatin 1 is a cyclic lipopeptide that has been shown to induce apoptosis in cells by inhibiting protein kinase activity. Bryostatin 1 induces the release of mitochondrial cytochrome c and other pro-apoptotic proteins from the mitochondria into the cytosol, which leads to cell death. This drug has also been shown to increase intracellular levels of Ca2+, leading to activation of proteases such as calpain. It also inhibits DNA methyltransferase, which may make it useful for the treatment of cancer.
Chemical properties
Technical inquiry about: 3D-IDA31401 Bryostatin 1
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