E-64

CAS: 66701-25-5

Ref. 3D-IES-4096

Product Information

• Name: E-64
• Synonyms: (2R,3R)-3-{[(2S)-1-({4-[(diaminomethylidene)amino]butyl}amino)-4-methyl-1-oxopentan-2-yl]carbamoyl}oxirane-2-carboxylic acid, (2S,3S)-3-[[[(1S)-1-[[[4-[(Aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-2-oxiranecarboxylic acid, (2S,3S)-3-{[(2S)-1-({4-[(diaminomethylidene)amino]butyl}amino)-4-methyl-1-oxopentan-2-yl]carbamoyl}oxirane-2-carboxylic acid, 2-Oxiranecarboxylic acid, 3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, (2S,3S)-, E 64 (proteinase inhibitor), E-64 Protease Inhibitor, E64, Oxiranecarboxylic acid, 3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, (2S,3S)-, Oxiranecarboxylic acid, 3-[[[1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, [2S-[2α,3β(R*)]]-, Proteinase inhibitor E 64, trans-Epoxysuccinyl-<span class="text-smallcaps">L</span>-leucylamido-(4-guanidino)butane, trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane, trans-epoxysuccinyl-L-leucylamido-*(4-guanidino)B

Description

E-64 is a chemical inhibitor that binds to the ATP synthase in mitochondria, inhibiting oxidative phosphorylation. This inhibition of mitochondrial energy production leads to cell death by apoptosis. E-64 has been shown to inhibit tumor growth in vitro and in vivo by inducing autophagy and inhibiting cancer cell proliferation. E-64 has also been shown to have proteolytic activity against serum proteins, which may be due to its ability to bind to the phosphate groups of proteins.

• Brand: Biosynth

Chemical properties

• Molecular weight: 366.42 g/mol
• Formula: C₁₅H₂₇N₅O₅H₂O
• Purity: Min. 95%