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(E/Z)-FK-506 26,28-allylic ester rearrangement impurity
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(E/Z)-FK-506 26,28-allylic ester rearrangement impurity

CAS: 131944-48-4

Ref. 3D-IF23294

2mg
201.00 €
5mg
334.00 €
10mg
502.00 €
25mg
832.00 €
50mg
1,252.00 €
Estimated delivery in United States, on Tuesday 22 Apr 2025

Product Information

Name:
(E/Z)-FK-506 26,28-allylic ester rearrangement impurity
Synonyms:
  • [3R-[3R*(1R*,3R*,4R*),4E,6S*,7S*,10R*,11E,14S*,16S*,17R*,18S*,20R*,21R*,28aS*]]-7,8,10,13,14,15,16,17,18,19,20,21,26,27,28,28a-Hexad ecahydro-7,21-dihydroxy-3-(4-hydroxy-3-methoxycyclohexyl)-16,18-dimethoxy-4,6,12,14,20-pentamethyl-10-(2-propenyl)-7,2
Description:

The impurity is a natural product and an API impurity. The impurity is synthesized by the rearrangement of (E/Z)-FK-506 26,28-allylic ester. This impurity has been shown to be present in drug products at concentrations up to 0.0025% w/w. It is found in analytical samples at concentrations up to 0.02% w/w, which may be due to its use as a HPLC standard. The impurity has been studied for metabolism in rats and rabbits and is not metabolized by microsomal enzymes or conjugated with glucuronic acid. The compound has also been shown to have anti-inflammatory properties in mice models and has no cardiotoxic effects on Balb/c mice.

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
804.02 g/mol
Formula:
C44H69NO12
Purity:
Min. 95%
MDL:
Melting point:
Boiling point:
Flash point:
Density:
Concentration:
EINECS:
Merck:
HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

Technical inquiry about: 3D-IF23294 (E/Z)-FK-506 26,28-allylic ester rearrangement impurity

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