Sitagliptin hydroxy amide impurity

CAS: 1253056-01-7

Ref. 3D-IS106472

Product Information

• Name: Sitagliptin hydroxy amide impurity
• Synonyms: 1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)-3-hydroxybutan-1-oneSitaglipti n impurity 13
• Brand: Biosynth
• Description: Sitagliptin is an oral dipeptidyl peptidase-4 inhibitor that is used to treat type 2 diabetes. It binds to the active site of the enzyme and reversibly blocks the action of the enzyme, thereby inhibiting the breakdown of a number of important hormones such as glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide. Sitagliptin hydroxy amide impurity is an impurity in sitagliptin that inhibits oxidoreductases, enzymes that catalyze oxidation reactions. The enantiomeric purity of sitagliptin hydroxy amide impurity is unknown.

Chemical properties

• Molecular weight: 408.3 g/mol
• Formula: C₁₆H₁₄F₆N₄O₂
• Purity: Min. 95%
• InChI: InChI=1S/C16H14F6N4O2/c17-10-6-12(19)11(18)4-8(10)3-9(27)5-14(28)25-1-2-26-13(7-25)23-24-15(26)16(20,21)22/h4,6,9,27H,1-3,5,7H2
• InChI key: InChIKey=GUBAVYYUZMCLIR-UHFFFAOYSA-N
• SMILES: O=C(CC(O)Cc1cc(F)c(F)cc1F)N1CCn2c(nnc2C(F)(F)F)C1