Triphenylmethanol

CAS: 76-84-6

Ref. 3D-IT28577

Product Information

• Name: Triphenylmethanol
• Synonyms: a,a-DiphenylbenzenemethanolZidovudine Impurity DHydroxytriphenylmethaneBL 3756, Bl 3756, Hydroxytriphenylmethane, Methanol, Triphenyl-, Nsc 4050, Trifenilmetanol, Triphenylcarbinol, Triphenylmethyl alcohol, Tritanol, Trityl alcohol, TrtOH, U 45483, α,α-Diphenylbenzenemethanol, alpha,alpha-diphenyl-benzenemethanol, Benzenemethanol, α,α-diphenyl-, Triphenyl carbinol, Triphenyl methanol

Description

Triphenylmethanol (TPM) is an inhibitor of the enzyme alcohol dehydrogenase. It is synthesized by reacting p-hydroxybenzoic acid with a hydroxyl group in the presence of trifluoroacetic acid and potassium carbonate. The reaction solution was then analyzed by x-ray crystallography, revealing the molecular structure of TPM. TPM binds to the metal ion in a hydroxyl group, preventing alcohol dehydrogenase from oxidizing ethanol to acetaldehyde. This mechanism also explains why TPM inhibits other enzymes that use this same metal ion cofactor such as carboxypeptidase A and aminopeptidase P, which are involved in protein synthesis and degradation.

Triphenylmethanol (TPM) is an inhibitor of the enzyme alcohol dehydrogenase. It is synthesized by reacting p-hydroxybenzoic acid with a hydroxyl group in the presence of trif

• Brand: Biosynth

Chemical properties

• Molecular weight: 260.33 g/mol
• Formula: C₁₉H₁₆O
• Purity: Min. 95%
• Color/Form: White Beige Slightly Yellow Powder
• InChI: InChI=1S/C19H16O/c20-19(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15,20H
• InChI key: InChIKey=LZTRCELOJRDYMQ-UHFFFAOYSA-N
• SMILES: OC(c1ccccc1)(c1ccccc1)c1ccccc1