Product Information
- GDC 0834
- N-[3-[6-[[4-[(2R)-1,4-Dimethyl-3-oxo-2-piperazinyl]phenyl]amino]-4,5-dihydro-4-methyl-5-oxo-2-pyrazinyl]-2-methylphenyl]-4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxamide
- Benzo[b]thiophene-2-carboxamide, N-[3-[6-[[4-[(2R)-1,4-dimethyl-3-oxo-2-piperazinyl]phenyl]amino]-4,5-dihydro-4-methyl-5-oxo-2-pyrazinyl]-2-methylphenyl]-4,5,6,7-tetrahydro-
GDC-0834 is an irreversible inhibitor of the enzyme tyrosine protein kinase. It has a pharmacokinetic profile that is similar to radiation and can be used as a replacement for radiation therapy. GDC-0834 selectively targets human liver, lung, and kidney cells, which are indicated by increased levels of apoptosis in these tissues. The molecule also inhibits the proliferation of hematopoietic cells, possibly due to its ability to cause mitochondrial membrane depolarization. GDC-0834 has been shown to have therapeutic efficacy against autoimmune diseases such as rheumatoid arthritis and psoriasis.
Chemical properties
Technical inquiry about: 3D-IVB43249 GDC-0834
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