Product Information
Name:Ac-YVAD-pNA
Synonyms:
- Ac-Tyr-val-ala-asp-paranitroanilide Caspase-1 substrate (chromogenic) Ac-Tyr-Val-Ala-Asp-Pna
Brand:Biosynth
Description:Ac-YVAD-pNA is a synthetic tetrapeptide inhibitor, which is primarily derived from specific peptide sequences designed to selectively inhibit cysteine protease activity. It acts by mimicking the natural substrates of the enzyme caspase-1 and competitively inhibiting its activity. The acetylated N-terminus (Ac-) and para-nitroanilide (pNA) group at the C-terminus facilitate the penetration across cell membranes and spectrophotometric measurement, respectively.Ac-YVAD-pNA is extensively utilized in biochemical research to investigate the role of caspase-1, which is a key player in inflammatory processes and apoptosis. By inhibiting caspase-1, researchers can study its involvement in the maturation of pro-inflammatory cytokines such as IL-1β and IL-18. The use of this inhibitor is crucial in elucidating the mechanisms of pyroptosis, a form of programmed cell death associated with inflammation. This tool aids in dissecting the pathways implicated in various diseases, including autoimmune disorders, neurodegenerative diseases, and infections, providing insights into potential therapeutic targets.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:628.63 g/mol
Formula:C29H36N6O10
Technical inquiry about: Ac-YVAD-pNA
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