10-506388 - 4-fluoro-2-methylphenoxy-acetic-acid | 451-88-7

[4-[[2-[3-Fluoro-4-(Trifluoromethyl)Phenyl]-4-Methyl-5-Thiazolyl]Methyl]Thio]-2-Methylphenoxy] Acetic Acid

<p>Applications A small molecule agonist of the human Peroxisome Proliferator-Activated Recept δ (PPAR δ). It shows an EC50 of 1.1 nM against PPAR δ with 100-fold selectivity over the other human subtypes.<br>References Sznaidman, M.L., et al.: Bioorganic and Medicinal Chemistry Letters, 13, 1517 (2003)<br></p>

<p>Applications GW0742 Sulfone is a possible metabolite of GW0742 (G930000) which is a small molecule agonist of the human Peroxisome Proliferator-Activated Recept δ (PPAR δ).<br>References Sznaidman, M.L., et al.: Bioorganic and Medicinal Chemistry Letters, 13, 1517 (2003)<br></p>

<p>Stability Light Sensitive<br>Applications GW0742 Sulfoxide is derived from GW0742 (G930000), which is small molecule agonist of the human Peroxisome Proliferator-Activated Receptor δ (PPAR δ). It shows EC50 of 1.1 nM against PPAR δ with 100-fold selectivity over the other human subtypes.<br>References Sznaidman, M.L., et al.: Bioorganic and Medicinal Chemistry Letters, 13, 1517 (2003);<br></p>

GW0742

GW0742 (GW610742) is an effective and specific PPARδ agonist (EC50: 1 nM/1.1 μM/2 μM, for human PPARδ/α/γ).

<p>Peroxisome proliferator-activated receptor PPARβ/Ύ agonist</p>

Versatile small molecule scaffold

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