Epoxomicin

CAS: 134381-21-8

Ref. 3D-JFA38121

Product Information

• Name: Epoxomicin
• Synonyms: (2R)-2-[Acetyl-(N-Methyl-L-Isoleucyl)-L-Isoleucyl-L-Threonyl-L-Leucyl]-2-Methyloxirane, <span class="text-smallcaps">L</smallcap>-Threoninamide, N-acetyl-N-methyl-<smallcap>L</smallcap>-isoleucyl-<smallcap>L</span>-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-, <span class="text-smallcaps">L</smallcap>-Threoninamide, N-acetyl-N-methyl-<smallcap>L</smallcap>-isoleucyl-<smallcap>L</span>-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-, Bu-4061T, Epoxomicin, Synthetic, N-Acetyl-N-Methyl-L-Isoleucyl-L-Isoleucyl-N-[(1S)-3-Methyl-1-[[(2R)-2-Methyloxiranyl]Carbonyl]Butyl]-L-Threoninamide, N-Acetyl-N-methyl-<span class="text-smallcaps">L</smallcap>-isoleucyl-<smallcap>L</smallcap>-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-<smallcap>L</span>-threoninamide, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-L-threonyl-N-{2-[(2R)-2-methyloxiran-2-yl]-2-oxoethyl}-L-leucinamide, N-acetyl-N-methyl-L-isoleucyl-N-{(2S,3R)-3-hydroxy-2-[(3-methyl-1-{[(2R)-2-methyloxiran-2-yl]carbonyl}butyl)amino]butanoyl}-L-isoleucinamide

Description

Epoxomicin is a macrolide antibiotic that inhibits the production of inflammatory mediators by suppressing the activity of protein kinase C. Epoxomicin has been shown to have anti-inflammatory properties in low doses. This drug also inhibits the proteasome, an enzyme that breaks down proteins into amino acids or small peptides, and is used as an inhibitor of cancer cell proliferation. Epoxomicin binds to the 20S proteasome at a site that is distinct from that for other proteasome inhibitors such as lactacystin and bortezomib, which are used for cancer treatment. The binding site for epoxomicin is adjacent to the ATP-binding site and may be due to its inhibitory effect on ATP hydrolysis.

• Brand: Biosynth

Chemical properties

• Molecular weight: 554.72 g/mol
• Formula: C₂₈H₅₀N₄O₇
• Purity: Min. 95%
• Color/Form: Powder