Product Information
Name:BMS-833923
Brand:Biosynth
Description:BMS-833923 is a small molecule that inhibits the activity of epidermal growth factor receptor (EGFR) tyrosine kinase in hypoxic tumor cells, which are found in approximately one-third of all solid tumors. BMS-833923 has been shown to inhibit EGFR tyrosine kinase activity by binding to the ATP site of EGFR and blocking the formation of ATP-EGFR complexes. The inhibition leads to a decrease in downstream signaling, including decreased activation of the mitogen-activated protein kinases and p38 MAPK pathways. BMS-833923 has also been shown to be active against metastatic pancreatic cancer cells. Pharmacokinetic studies have shown that BMS-833923 is metabolized via CYP3A4/5; however, this does not affect its antitumor activity or toxicity.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:473.58 g/mol
Formula:C30H27N5O
Purity:Min. 95%
Technical inquiry about: BMS-833923
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