Product Information
PF-06815345 is a kinetic convertase inhibitor that binds to the active site of the enzyme, inhibiting its activity. This compound has been shown to inhibit human low-density lipoprotein (LDL) cholesterol production in vitro and reduce plasma LDL-cholesterol levels in vivo. The mechanism of action of PF-06815345 is not clear, but it may be due to inhibition of statin catalysis, which leads to a decrease in the level of functional LDL receptors on liver cells. The drug also inhibits the activity of serine proteases such as subtilisin and kexin type enzymes. In addition, PF-06815345 has been shown to be an organocatalyst for low-temperature aldehyde synthesis, with tetrazole as a key intermediate. It is also used for treatment of cardiovascular diseases such as high blood pressure and elevated levels of low density lipoprotein cholesterol (LDL-C).
Chemical properties
Technical inquiry about: 3D-JTD43449 PF-06815345
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