Product Information
- 1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride
- 1-(4,4-Diphenylbut-3-En-1-Yl)Piperidine-3-Carboxylic Acid Hydrochloride
- 3-Piperidinecarboxylic acid, 1-(4,4-diphenyl-3-buten-1-yl)-, hydrochloride (1:1)
- 3-Piperidinecarboxylic acid, 1-(4,4-diphenyl-3-butenyl)-, hydrochloride
- 4-(3-Carboxypiperidine)-1,1-diphenyl-1-butene hydrochloride
- Skf 89976A
SKF-89976A is a potent, selective inhibitor of the uptake of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) into synaptic vesicles. SKF-89976A has been shown to inhibit the uptake of GABA and diazepam in rat brain synaptosomes and to have antiepileptic activity in rats. It also binds to GABA receptors with low affinity. SKF-89976A has been localized to granule cell axons, where it inhibits GABA release, and to presynaptic terminals, where it inhibits GABA uptake. SKF-89976A is expressed in animals as well as in human tissues.
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SKF-89976A was discovered by scientists at SmithKline Beecham Pharmaceuticals (now GlaxoSmithKline) who were looking for drugs that could raise seizure threshold levels during clinical trials on epilepsy patients.BR>BR>
The drug was
Chemical properties
Technical inquiry about: 3D-KDA37515 SKF-89976A
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