Product Information
- Pd 173955
- 6-(2,6-Dichlorophenyl)-8-methyl-2-[[3-(methylthio)phenyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one
PD173955 is a potent, selective and orally bioavailable inhibitor of the Abl kinase that has been shown to inhibit tumor growth in mouse models. PD173955 binds to the ATP-binding site of Abl kinase and blocks ATP binding, preventing the formation of an enzyme-substrate complex. PD173955 also inhibits colony-stimulating factor activity, which may be due to its inhibition of bcr-abl kinase activity.
Chemical properties
Technical inquiry about: 3D-KKA41563 PD173955
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