Cereblon modulator 1

CAS: 1860875-51-9

Ref. 3D-KZC87551

Product Information

• Name: Cereblon modulator 1
• Brand: Biosynth
• Description: Cereblon modulator 1 is a prodrug that binds to the E3 ubiquitin ligase, Cereblon, and blocks its activity. This drug is being studied for use in hematologic malignancies. Cereblon modulator 1 has been shown to inhibit the proliferation of myelodysplastic cells by inducing c-myc protein degradation and inhibiting IL-1 receptor activation. The drug also inhibits the growth of cancer cells by blocking the Tautomerase function of Cereblon, thereby preventing the conversion of inactive proteins into active proteins. Cereblon modulator 1's linker is heterocyclic, which is likely responsible for its antagonist effect on IL-1 receptor activation.

Chemical properties

• Molecular weight: 461.8 g/mol
• Formula: C₂₂H₁₈ClF₂N₃O₄
• Purity: Min. 95%