GSK 2193874
CAS: 1336960-13-4
Ref. 3D-LDC96013
| 5mg | 172.00 € | ||
| 10mg | 248.00 € | ||
| 25mg | 436.00 € | ||
| 50mg | 518.00 € | ||
| 100mg | 739.00 € |
Product Information
GSK2193874 is a potent and selective small molecule for the treatment of chronic cough. It inhibits the activation of TRPV4, which is a member of the transient receptor potential cation channel family, in primary cells by pharmacological agents and in vitro by intracellular Ca2+ levels. GSK2193874 has been shown to inhibit acetylcholinesterase activity and to increase cytosolic calcium levels in atrial myocytes. This drug also has effects on congestive heart failure (CHF) patients, such as an increase in left ventricular function and improved pulmonary hemodynamics. GSK2193874 also binds to toll-like receptor 4 (TLR4), which may be a therapeutic target for the treatment of chronic cough.
Chemical properties
Technical inquiry about: 3D-LDC96013 GSK 2193874
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