Product Information
- (R)-Tetrahydrofuran-3-Amine
- R-(+)-3-Aminotetrahydofuran
- (3R)-Tetrahydrofuran-3-Amine
- (3R)-oxolan-3-amine
(R)-Tetrahydrofuran-3-amine is a nucleoside phosphorylase inhibitor that binds to the catalytic site of the enzyme, inhibiting the synthesis of purine nucleotides. This drug has been shown to be effective in treating atrial fibrillation. (R)-Tetrahydrofuran-3-amine has also been used as a lead compound for the development of analogues with improved inhibitory potency and selectivity for adenosine receptors. The synthetic scheme for this compound starts by reacting 1,4-dihydropurine with aldehyde and formaldehyde under acid conditions. The product is then condensed with 2,2-dimethylpropane-1,3-dione to yield an intermediate that is oxidized and reduced to produce the final product. This process can be carried out using high performance liquid chromatography (HPLC) methods.
Chemical properties
Technical inquiry about: 3D-LEA76926 (R)-Tetrahydrofuran-3-amine
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