Product Information
AES-135 is a hydroxamic acid that inhibits histone deacetylase (HDAC). It has been shown to be effective in treating cancer cells. AES-135 binds to HDACs and prevents them from removing acetyl groups from lysine residues on histones, which prevents the transcription of genes. This drug has been shown to inhibit the growth of pancreatic cancer cells in culture, but it is not known if this effect occurs in humans. A phase I clinical trial with AES-135 was conducted in patients with pancreatic cancer, but the results were inconclusive. Preclinical studies have shown that this drug can be used as a treatment for breast cancer, leukemia, and other cancers.
Chemical properties
Technical inquiry about: 3D-LUD65961 AES-135
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