Product Information
Ischemia reperfusion injury is a major cause of irreversible brain damage. The enzyme GTPase-activating protein (GAP) has been shown to be involved in the regulation of cell death and may represent a potential therapeutic target for ischemia reperfusion injury. MG132 is an inhibitor of GAP and can protect against brain damage in wild-type mice subjected to cerebral ischemia reperfusion injury. MG132 blocks protein synthesis, leading to apoptotic cell death in cancer cells, while it induces apoptotic cell death in cancer cells. MG132 also inhibits proteasome activity and leads to acute ischemic brain damage in wild-type mice.
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Technical inquiry about: 3D-LYB87736 (R)-MG 132
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