Product Information
- 5-O-phosphono-D-arabinose
- <span class="text-smallcaps">D</span>-Arabinose 5-phosphate
- <span class="text-smallcaps">D</span>-Arabinose, 5-(dihydrogen phosphate)
- Arabinose 5-Phosphate
- D-arabinose-5-P
D-Arabinose-5-phosphate is an intermediate in the pentose phosphate pathway. It is synthesized from D-xylulose-5-phosphate by xylitol dehydrogenase. D-Arabinose-5-phosphate inhibits the enzyme xylitol dehydrogenase, which converts xylulose to d-xylulose, and thus prevents the formation of 5-hydroxyisoxazole phosphate, a precursor to the synthesis of NADPH. In this way, it blocks the synthesis of NADPH, which is essential for aerobic metabolism. This inhibition leads to a decrease in ATP production and consequently cell death.
D-Arabinose is also an intermediate in the arabinan biosynthesis pathway. The enzyme arabinan synthetase catalyzes the reaction between darabinose and UDP to form arabinan. Structural analysis has shown that there are three distinct regions on this enzyme: a
Chemical properties
Technical inquiry about: 3D-MA03841 D-Arabinose-5-phosphate
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