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(S)-3-((3aR,5R,6S,6aR)-6-(Benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)propane-1,2-diol
CAS: 871347-98-7
Ref. 3D-MB45373
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Product Information
- 3-O-Benzyl-5-deoxy-1,2-O-isopropylidene-a-D-gluco-heptofuranose
(S)-3-((3aR,5R,6S,6aR)-6-(Benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)propane-1,2-diol is a guanosine triphosphatase inhibitor that binds to the enzyme and blocks its activity. It also has anti-cancer properties due to its ability to inhibit DNA methylation. The drug is activated by nitro groups in the presence of formaldehyde or formic acid to give 3-(N-nitrosomethyl)benzoyloxymethyl butyrylguanine (NMGB). This metabolite is then hydrolyzed into an aldehyde and dialkylamino group which are thought to be responsible for the anticancer activity. NMGB inhibits cancer cell growth by inhibiting protein synthesis and reducing metabolic activities.
Chemical properties
Technical inquiry about: 3D-MB45373 (S)-3-((3aR,5R,6S,6aR)-6-(Benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)propane-1,2-diol
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