1-Chloro-2-deoxy-3,5-di-O-toluoyl-a-D-ribofuranose

CAS: 4330-21-6

Ref. 3D-MC02788

Product Information

• Name: 1-Chloro-2-deoxy-3,5-di-O-toluoyl-a-D-ribofuranose
• Synonyms: 2-Deoxy-3,5-di-O-(4-toluoyl)-a-D-erythro-pentofuranosyl chloride3,5-Di-O-4-toluoyl-2-deoxy-D-ribofuranosyl chlorideHoffer's a-chlo ro sugar, (2R,3S,5R)-5-Chloro-2-[[(4-methylbenzoyl)oxy]methyl]tetrahydrofuran-3-yl] 4-methylbenzoate, 1-Chloro-2-deoxy-3,5-di-O-p-toluoyl-α-<span class="text-smallcaps">D</span>-erythro-pentofuranose, 1-Chloro-2-deoxy-3,5-di-O-p-toluoyl-α-<span class="text-smallcaps">D</span>-ribose, 1-Chloro-2-deoxy-3,5-di-O-toluoyl-D-ribofuranose, 1-Chloro-2-deoxy-3,5-di-O-toluoyl-a-<span class="text-smallcaps">D</span>-ribofuranose, 1-alpha-Chloro-3,5-di-O-(4-toluoyl)-2-deoxy-D-ribofuranose, 1-α-Chloro-3,5-ditoluoyl-2-deoxy-<span class="text-smallcaps">D</span>-ribose, 2-Deoxy-3,5-di-O-p-toluoyl-α-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl chloride, 2-Deoxy-alpha-D-erythropentofuranosyl chloride 3,5-bis(4-methylbenzoate), 2-deoxy-3,5-bis-O-(4-methylbenzoyl)-alpha-D-erythro-pentofuranosyl chloride, 2-deoxy-3,5-bis-O-(4-methylbenzoyl)pentofuranosyl chloride, 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride, 3,5-Di-O-p-toluyl-2-deoxy-α-<span class="text-smallcaps">D</span>-ribofuranosyl chloride, 3,5-Di-O-toluoyl-α-1-chloro-2-deoxy-<span class="text-smallcaps">D</span>-ribofuranose, <span class="text-smallcaps">D</span>-erythro-Pentofuranosyl chloride, 2-deoxy-, di-p-toluate, α-, Hoffer's chlorosugar, Hoffer's sugar, Hoffer's α-chlorosugar, NSC 148837, p-Toluic acid, diester with 2-deoxy-α-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl chloride, α-<span class="text-smallcaps">D</span>-erythro-Pentofuranosyl chloride, 2-deoxy-, 3,5-bis(4-methylbenzoate), α-<span class="text-smallcaps">D</span>-erythro-Pentofuranosyl chloride, 2-deoxy-, bis(4-methylbenzoate)
• CAS: 4330-21-6

Description

1-Chloro-2-deoxy-3,5-di-O-toluoyl-a-D-ribofuranose (also known as Hoffer’s chlorosugar) is a synthetic building block used in nucleic acid research to afford an array of both alpha and beta linked 2’-deoxyribose derivatives. Naturally occurring nucleosides are typically beta linked and the efficient synthesis of alpha linked analogues, which are often more stable, offers access to interesting variations in 3D structure and biochemical reactivity.

• Brand: Biosynth

Chemical properties

• Molecular weight: 388.84 g/mol
• Formula: C₂₁H₂₁ClO₅
• Purity: Min. 90 Area-%
• Color/Form: Powder
• InChI: InChI=1S/C21H21ClO5/c1-13-3-7-15(8-4-13)20(23)25-12-18-17(11-19(22)26-18)27-21(24)16-9-5-14(2)6-10-16/h3-10,17-19H,11-12H2,1-2H3/t17-,18+,19-/m0/s1
• InChI key: InChIKey=FJHSYOMVMMNQJQ-OTWHNJEPSA-N
• SMILES: Cc1ccc(C(=O)OC[C@H]2O[C@H](Cl)C[C@@H]2OC(=O)c2ccc(C)cc2)cc1