Thiamet G

CAS: 1009816-48-1

Ref. 3D-MD08856

Product Information

• Name: Thiamet G
• Synonyms: 1,2-Dideoxy-2'-ethylamino-a-D-glucopyranoso-[2,1-d]-2'-thiazoline(3aR,5R,6S,7R,7aR)-2-(Ethylamino)-3 a,6,7,7a-tetrahydro-5-(hydroxy methyl)-5H-pyrano[3, 2-d]thiazole-6,7-diol
• Brand: Biosynth
• Description: Inhibits β-N-acetylglucosaminidase, also known as O-GlcNAcase (OGA), which cleaves the O-linked glycans from glycoproteins. Interferes with O-GlcNAc cycling and leads to the accumulation of O-GlcNAcylated proteins. Thiamet G elicits neuroprotective effects by modulating microglia/macrophages and inhibiting hyperphosphorylation of the microtubule-associated protein tau in models of stroke and Alzheimer’s disease. Thiamet G also has implications on diabetes and cardiovascular pathologies.

Chemical properties

• Molecular weight: 248.3 g/mol
• Formula: C₉H₁₆N₂O₄S
• Purity: Min. 95%
• Color/Form: Powder