Product Information
- L-quinovose
- L-6-Deoxyglucose
- L-Chinovose
- L-Isorhamnose
- L-Quinovose
6-Deoxy-L-glucose (6DG) is a glucose analogue that has been extensively studied for its effect on the metabolism of other sugars. It is an inhibitor of glycolysis and the pentose phosphate pathway in both wild-type and mutant strains of yeast, as well as in mammalian cells. 6DG inhibits the activity of enzymes such as gamma-aminobutyric acid (GABA) transaminase and phosphoglycerate kinase, which are involved in the synthesis of GABA and glycogen respectively. 6DG also inhibits the transport of sugar molecules into cells. The hydrochloric acid (HCl) concentration required to activate 6DG varies with pH, with a pKa near 7.5 at physiological pH. 6DG is activated by HCl when the pH falls below this value. The hydroxyl group on 6DG can react with HCl to form a chlorohydrin intermediate, which reacts further to yield
Chemical properties
Technical inquiry about: 3D-MD163281 6-Deoxy-L-glucose
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