2-Deoxy-2-fluoro-D-glucose 6-phosphate barium salt

CAS: 40871-47-4

Ref. 3D-MD31750

Product Information

• Name: 2-Deoxy-2-fluoro-D-glucose 6-phosphate barium salt
• Synonyms: 2-Fluoro-2-deoxyglucose-6-phosphate, 2-Deoxy-2-fluoroglucose 6-phosphate, 2-Fdgup, 2-Fluoro-2-deoxy-D-glucose-6-phosphate, Fdg-6-P, D-Glucose, 2-deoxy-2-fluoro-, 6-(dihydrogen phosphate), 2-deoxy-2-fluoro-6-O-phosphono-D-glucose

Description

2-Deoxy-2-fluoro-D-glucose 6-phosphate barium salt is a glucose analogue used in positron emission tomography (PET) imaging of cancer. It is an inhibitor of glycolysis and phosphofructokinase, which are enzymes that catalyze the conversion of glucose to pyruvate. 2-Deoxy-2-fluoro-D-glucose 6-phosphate barium salt is taken up by the cell by active transport, then metabolized into 2 deoxy 2 fluoro D mannose phosphate and finally converted to glucosylceramide. The PET scan detects the accumulation of this molecule in cells with high glycolytic activity, such as cancer cells. This compound has been shown to inhibit hepatocellular carcinoma (HCC) cell growth in vitro and in vivo.

• Brand: Biosynth

Chemical properties

• Molecular weight: 397.44 g/mol
• Formula: C₆H₁₀FO₈P·Ba
• Purity: Min. 95%
• Color/Form: Powder