1-Deoxythiomannojirimycin
Ref. 3D-MD63577
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Product Information
- (2R,3S,4R,5S)-3,4,5-Trihydroxy-2-hydroxymethylthiane
1-Deoxythiomannojirimycin is a potent inhibitor of glycosidases, including α-amylase, β-glucanase, and α-glucosidase. This compound has been synthesized from thiomannose and jirimycin. Thiomannose is a natural compound that can be found in almond extract or as a byproduct of the hydrolysis of mannitol during hydrogenation. It can also be produced enzymatically from glucose by using β-mannosidase or α-mannosidase. 1-Deoxythiomannojirimycin inhibits the activity of glycosidases by forming an irreversible covalent bond with the active site serine hydroxyl group on the enzyme. This inhibits the cleavage of substrates such as starch into reducing sugars (e.g., glucose) and disaccharides (e.g., maltose).
Chemical properties
Technical inquiry about: 3D-MD63577 1-Deoxythiomannojirimycin
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