5-Fluorouracil N-b-D-glucuronide
CAS: 66048-45-1
Ref. 3D-MF16727
| 5mg | To inquire | ||
| 10mg | To inquire | ||
| 25mg | To inquire | ||
| 50mg | To inquire | ||
| 100mg | To inquire |
Product Information
- 1-Deoxy-1-(5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-b-D-glucopyranuronic acid5-Fluoro-1-(b-D-glucuronopyranosyl)uracil
5-Fluorouracil N-b-D-glucuronide is the major metabolite of 5-fluorouracil. It is mainly excreted in urine and bile, and has a high blood level. The glucuronide conjugate of 5-fluorouracin is hydrolyzed by beta-glucuronidase to generate 5-fluorouridine, which can be reabsorbed into the cell to form cytotoxic 5-fluoro uridine triphosphate. This process inhibits protein synthesis, leading to cell death. The half life of 5FU glucuronide is short and it needs to be constantly replaced with new doses. It has also been shown that levels of 5FU glucuronide are higher in tissues than in plasma, which may explain its inhibitory effect on tumors.
Chemical properties
Technical inquiry about: 3D-MF16727 5-Fluorouracil N-b-D-glucuronide
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