Cis-atovaquone
CAS: 137732-39-9
Ref. 3D-MFA73239
| 1mg | 172.00 € | ||
| 5mg | 436.00 € | ||
| 10mg | 647.00 € | ||
| 25mg | 924.00 € | ||
| 50mg | 1,275.00 € |
Product Information
Cis-atovaquone is an effective drug that inhibits the growth of Plasmodium falciparum, a parasite responsible for malaria. It works by binding to the cytochrome bc1 complex in the mitochondrial electron transport chain and disrupting the production of ATP, which is essential for DNA synthesis and protein production. Cis-atovaquone has been shown to have a strong inhibitory effect on liver mitochondria and has high catalytic efficiency. Molecular docking studies suggest that it binds to the active site of the enzyme and forms intermolecular interactions such as hydrogen bonds with amino acid residues. Crystal structures of the protein-inhibitor complex provide insights into its mechanism of action. In control mice, Cis-atovaquone has been shown to be highly effective against malaria infections, making it a promising candidate for future treatments.
Chemical properties
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